diff --git a/roles/custom/matrix-synapse/vars/main.yml b/roles/custom/matrix-synapse/vars/main.yml
index 8843c0600..55943645b 100644
--- a/roles/custom/matrix-synapse/vars/main.yml
+++ b/roles/custom/matrix-synapse/vars/main.yml
@@ -26,6 +26,8 @@ matrix_synapse_workers_room_worker_federation_endpoints:
 # Sync workers handle /sync and the (now deprecated) related endpoints
 matrix_synapse_workers_sync_worker_client_server_endpoints:
   - ^/_matrix/client/(api/v1|r0|v3|unstable)/(sync|events|initialSync|rooms/[^/]+/initialSync)$
+  # Native Sliding Sync (MSC3575) - supported on generic workers since Synapse 1.114
+  - ^/_matrix/client/unstable/org.matrix.simplified_msc3575/sync$
 
 # Client reader workers handle generic client-server endpoints that don't contain a roomid or sync
 matrix_synapse_workers_client_reader_client_server_endpoints:
@@ -149,6 +151,8 @@ matrix_synapse_workers_generic_worker_endpoints:
   - ^/_matrix/client/(api/v1|r0|v3)/events$
   - ^/_matrix/client/(api/v1|r0|v3)/initialSync$
   - ^/_matrix/client/(api/v1|r0|v3)/rooms/[^/]+/initialSync$
+  # Native Sliding Sync (MSC3575) - supported since Synapse 1.114
+  - ^/_matrix/client/unstable/org.matrix.simplified_msc3575/sync$
 
   # Federation requests
   - ^/_matrix/federation/v1/event/